[theorvs]

I have a sandrail with a 2165cc 94X78 Engle VZ14 Cam Empi GTV-2 Stage 3 heads 44x37.5 1.1 rockers dual weber 44s idf with 55 idle jets and 140 main jets Correction jets F11 ventures are stock all MSD ignition box distributor coil and wires plugs gapped at 50 thousands electric fuel pump 1"5/8 bobcat exhaust for some reason I'm fouling the #1 plug and running rough something doesn't seem right Help please

 

[cannonfoddertfc]

Just fouling #1 and none of the others? Does not sound like a fuel problem, sounds like a spark or cylinder/head problem.
Exchange the plug and wire with #2 and see if the problem moves to the #2. This will at least help narrow it down.
If the problem moves, replace wire and/or plug.
If the problem does not move with the wire/plug, you will want to do a compression check.